Study the Effects of Anti-inflammatory Curcumex Capsules Containing Three Plants (ginger, Curcumin and Black Pepper) in Patients with Active Rheumatoid Arthritis

Background: RA is an autoimmune disease that presented with chronic inflammation due to synovial hyperplasia, this disease progress through joint destruction. DMARD s is the most usual drug for treating this disease that accompanies with various adverse effects and complications. Aim of this study is to evaluate anti-inflammatory effect of a compound herbaceous drug consist of (ginger, Curcumin and black pepper) in rheumatoid patients so that decreasing dosage of DMARD s. Method: 60 patients with Rheumatoid Arthritis upon ACR2010 criteria, enrolled study and divided to two groups consist of 30 patients. Both group received routine treatment of anti-rheumatoid agent consist of Methotrexate as DMARD, prednisolon and Hydroxychloroquine (HCQ) , one group received compound herbal drug named Curcumex consist of (ginger, Curcumin and black pepper) and control group received placebo as a same dose. Before and after 8 weeks DAS 28 score, TJC, SJC, ESR and CRP was calculated and compared in two groups. Result:s: Curcumex reduces TJC AND SJC significantly rather than placebo in patients with rheumatoid arthritis. Also DAS Score 28 decreased in Curcumex group rather than placebo (p-value<0.001). Laboratory markers such as ESR decreased in patients group, but there were no differences between two groups in CRP scales. (Value=0.322)